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Semaglutide: a price and HTA comparison between US and top European markets
Ozempic in the US is known for having higher list prices for drugs than other high-income countries. But these higher prices have not deterred investment and US patient usage of diabetes/weight-loss drugs, such as semaglutide.
While Medicare is not allowed to cover weight loss drugs under current law and Medicaid coverage varies by state, the US, like its counterparts in Europe, is seeing an increased interest in these drugs.
GlobalData has therefore analysed the price differences between the popular drug, semaglutide, in the US, compared to the top five European markets (France, Germany, Italy, Spain and the UK).
Other factors considered include how the average first price change is seen in each market, the time to first price change, and how respective health technology assessment (HTA) outcomes vary between semaglutide brands and all drugs indicated for the treatment of obesity or diabetes across the Europe top five and the US.
Launch cost lower in the top five European markets
Semaglutide was first launched in the US in December 2017 by Novo Nordisk, under the brand name Ozempic, for the treatment of type 2 diabetes and as an “add on” to other diabetes medicines, at a manufacturer price of $676.00. It is currently the only brand of semaglutide available in all top five European markets and the US.
Along with the drug’s increased popularity and expanded use, including off-label treatments for weight loss, other brands of semaglutide were then launched by Novo Nordisk under the names Rybelsus and, most recently, Wegovy. Of the semaglutide brands, only Wegovy has been approved for weight loss, together with diet and physical activity.
It is not uncommon for an active ingredient that has been used for an off-label indication to then be approved under a different brand with a higher price.
Global Data has compared the average daily cost at launch of these different brands of semaglutide across the top five European markets and the US based on a defined daily dose (DDD) of 0.11mg for those brands delivered parenterally (Ozempic and Wegovy) and 10.5mg for the orally administered Rybelsus.
While the daily dose for Wegovy is higher in practice, 0.11mg was used to allow for a direct comparison of the two semaglutide products that have the same dosage form. For the US, the “Big 4” and wholesale acquisition cost (WAC) prices were used to calculate the daily cost.
Since the Big 4 price is the maximum price a manufacturer can charge the big four federal agencies (Department of Veterans Affairs [VA], the Department of Defense [DoD], the Public Health Service, and the Coast Guard), it offered a price control measure comparable to that of the reviewed European markets.
All three products achieved their highest average daily cost at launch in the US, ranging from $16.77 for Ozempic to $45.55 for Wegovy.
Compared to the US, the average daily cost of Ozempic at launch in the top five European markets ranged between 183% and 267% lower, with the lowest in France at $4.56.
The most recent version of semaglutide, Wegovy, has the highest daily cost at launch of a semaglutide product in each of its markets (France, Germany and the US).
However, its daily cost in France was still 143% lower than its daily cost at launch in the US, and even lower in Germany – 572% lower when compared to the US.
Wegovy’s lower cost in Germany compared to the other European markets is likely due to the drug not being reimbursed there. A decision to compensate a lower price for a higher volume of sales may therefore have been made. It is worth noting, however, that a direct comparison cannot be made between Wegovy and the other brands. While the drug is also a semaglutide product, its higher cost is justified by a higher dosage that aligns with its approval specifically for weight loss.
Diabetes/obesity drugs retain launch price for longer in Europe’s top-5 than the US
Ozempic, Rybelsus and Wegovy have undergone price changes in at least one of these markets. According to GlobalData, Ozempic was able to maintain its launch price for the longest time in France (1,459 days) before receiving a price cut.
In Figure 3, the average first price change for all drugs that have been indicated for the treatment of obesity or diabetes (including those molecules that have been genericised) across Europe’s top 5 markets and the US were reviewed and compared against the average price change of Ozempic, Rybelsus and Wegovy.
In France, the average price change for Ozempic (-3.69%) was significantly lower than the overall average for all diabetes/obesity medicines (-9.68%). A similar trend is seen in Spain, where Ozempic took a price cut of only 6% compared to the overall average of 13.84%.
In Germany, Ozempic took a much greater cut (-21.17%) when compared to the overall average for diabetes/obesity drugs (-11.87%). After launching in Italy, Ozempic saw a different trend, however, and received a price increase of 5.27% while on average, weight loss medicines typically saw a price reduction of 7.47% for their first price change. In the US, both Rybelsus and Ozempic received price increases – 5.33% and 6.36% respectively – which aligned with the overall average for diabetes/obesity medicines of 5.49%.
Because of Wegovy’s brief time on the market so far compared to Ozempic, the drug has not yet undergone a price change in the top five European markets and its WAC price remains the same in the US. However, the drug’s Big 4 price has undergone a series of minor price increases.
The average first price increase for Wegovy’s Big 4 price was roughly 1%.
Ozempic For Sale
Ozempic is a medication used to treat type 2 diabetes. It belongs to a class of drugs called GLP-1 receptor agonists, which work by stimulating the release of insulin and slowing down the digestion of food.
This helps to control blood sugar levels in people with diabetes. Ozempic is administered once a week through a subcutaneous injection, and it has been shown to be effective in lowering HbA1c levels and promoting weight loss.
There are several reasons why it is may be for sale. Firstly, it could be that the medication is no longer needed by the person who initially purchased it.
This could be due to a change in their diabetes management plan or the introduction of a different medication.
In such cases, individuals may choose to sell their unused Ozempic to recoup some of the cost.
Another reason why it may be for sale is that the person who purchased it may have experienced adverse effects or found that it was not effective in managing their diabetes.
In these cases, individuals may choose to sell their unused medication as they no longer have a need for it.
It is important to note that selling prescription medications without the proper authorization is illegal in many countries.
In addition, purchasing medications from unauthorized sources can be risky as the quality and authenticity of the medication cannot be guaranteed.
It is always recommended to consult with a healthcare professional and obtain medications from reputable sources.
In conclusion, Ozempic is a medication used to treat type 2 diabetes.
It may be for sale for various reasons, such as no longer needing the medication or experiencing adverse effects.
However, it is important to abide by the law and consult with a healthcare professional before purchasing or selling any medications.
Visit our store online ozempicstoreonline.com for your ozempic drug and dosage prescription which will help you become the person you want to become.
Wegovy For Sale
Wegovy is a revolutionary online platform for buying and selling goods that enables customers to access the largest selection of goods from all over the world quickly and easily.
Our sophisticated e-commerce system allows businesses and entrepreneurs to list their products, display full detailed listings including photos, descriptions, reviews, and pricing info.
Customers can search, compare, and purchase items from within our accessible web interface with just a few clicks.
We have established strategic partnerships with major suppliers in every industry block to provide customers with the lowest prices for quality goods. Through our automated system of inventory management and delivery tracking capabilities, customers enjoy seamless transactions at every stage of the sales process.
With our streamlined customer service team always on hand to provide thorough guidance throughout the entire buying experience, wegovy has redefined the way businesses buy and sell goods online.
Our comprehensive suite of services also includes marketing support for sellers to help them promote their products through organic targeted advertising campaigns as well as marketplaces that allow buyers to compare prices.
Moreover, we offer integrated payment solutions such as PayPal checkout processes and direct bank transfers, eliminating traditional costs associated with digital transactions while providing unparalleled security measures.
Additionally, buyers are protected by various guarantees offered through our extensive buyer protection program designed to ensure complete confidence in any purchase.
At Wegovy, it is our mission to remain at the forefront of retail technology solutions in order to enhance customer satisfaction levels from start to finish – allowing businesses of all sizes across industries gain access to quality merchandise that they can trust without breaking the bank!
Semaglutide For Sale
Semaglutide is a type of glucagon-like peptide-1 (GLP-1) analog used to treat type 2 diabetes.
It works by increasing the production of insulin and making the body more sensitive to it, enabling the body to lower blood sugar levels better.
Semaglutide comes in three forms: tablets, an injection, and a once-weekly injection.
Although semaglutide is not yet available over the counter, there are pharmacies and online retailers that sell semaglutide for sale.
To buy semaglutide online or from physical pharmacies, patients need to provide their doctors’ prescription first to be sure that the medication is safe and effective for them.
Injection pens sold through online retailers also come with detailed instructions regarding preparation and administration of the medication.
Additionally, patients can expect their local pharmacy or online retailer to make sure they have adequate supply for their needs; if not, they may be able to purchase larger amounts at discounted prices.
Although cost is always a factor when selecting medication, patients can feel assured that purchasing semaglutide for sale from reputable companies will ensure they are getting quality product delivered promptly right at their doorsteps.
Packaging And Shipment Services
1. By Express
——Suitable for under 50kg, Fast:3-7 days.
High cost; Door to door service. Easy to pick up the goods.
2. By Air
——Suitable for more than 50 kg, Fast:3-7 days,
High cost, airport to airport. professional broker needed.
3. By sea
——Suitable for more than 500kg. Slow: 5-45 days,
Low cost. Port to Port, professional broker needed.
